Clusterin
Another molecule (Clusterin) has been discovered that protects the brain from inflammation and is generated by exercise. Several years ago, neuroscientists discovered irisin as a protection for brain inflammation that is produced by exercise.
The current concept regarding dementia is that it occurs due to chronic inflammation in the brain with resultant scar tissue (amyloid plaque). In this regard scientists have studied patients with early dementia and have found an improvement in cognitive function via a daily exercise routine. The exercise leads to increased production of both irisin and Clusterin.