HANE (HAE)
A recent New England Journal of Medicine had three articles and an editorial about hereditary angioedema previously called hereditary angioneurotic edema. By way of reminder, HAE causes recurrent episodes of swelling that can affect various parts of the body: face, tongue, throat, abdomen, extremities. It is caused by a gene mutation in SERPING 1 which controls the production of C1-inhibitor. In type 1 HAE there is a deficiency of the inhibitor, in type 2 the inhibitor protein is present but…