More lung injury from smoking
Researchers at the University of Alabama Medical Center have discovered a new reason cigarette smoke causes lung damage. They found that smoke inhibits leukotriene A4 hydrolase (LTA4A). This molecule is important in shutting down white blood cells following a successful response to inflammation. By not shutting down white blood cells, smokers experience ongoing inflammatory damage to the lung and airways; this leads to COPD and emphysema. The same researchers also discovered previously unknown substrata of LTA4H called proline-glycine-proline (PGP), which…