Dermatoporosis is a newly minted word to describe the age-related decline of our largest organ: our skin. We have similar terms for other organs: congestive heart failure, COPD, macular degeneration and osteoporosis.  

The value of a new term is that it directs patient/physician attention to the problem and ways to improve it. Other than advancing age, other risk factors include solar damage, topical or systemic steroids, renal disease, COPD, anticoagulant use and lack of exercise. A common (physiologic) denominator to all these risk factors is loss of extra cellular matrix (ECM). The ECM is the vital scaffolding that supports and nourishes our skin cells and is comprised of an interwoven network of collagen and elastin fibers. The principal constituent of ECM is hyaluronic acid, which is produced by a cellular organelle, the hyaluronosome. A depleted ECM leads to skin thinning and skin fragility which in turn lead to the purpura (flat bruises) and skin tears that occur.  

Dermatoporosis can be prevented or improved by some simple measures. Using sunscreen or solar clothing reduce UV damage. Topical retinoids help thicken the skin and improve resilience Emollients with alpha-hydroxy acid also increase skin thickness. In women topical DHEA (dehydroepiandrosterone) is of significant value. Finally, ensuring adequate dietary protein intake helps.