{"id":72,"date":"2011-01-21T15:10:34","date_gmt":"2011-01-21T15:10:34","guid":{"rendered":"http:\/\/www.allergy-associates.com\/?p=72"},"modified":"2011-01-21T15:10:34","modified_gmt":"2011-01-21T15:10:34","slug":"asthma-study-shows-common-airway-barrier-adds-to-bank-of-asthma-knowledge","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=72","title":{"rendered":"Asthma study shows common airway barrier, adds to bank of asthma knowledge"},"content":{"rendered":"<p>Last month the lead article in the <em>New England Journal of Medicine<\/em>\u00a0was titled &#8220;A Large-Scale, Consortium-Based Genome-Wide Association Study of Asthma&#8221;, and was from work done by the National Heart and Lung Institute in the U.K.<\/p>\n<p>It was a detailed, in-depth study that led to two major findings: First, asthma is genetically heterogenous.\u00a0 This fact accounts for the variability in the illness itself, and also to the variability in response to treatments.\u00a0 That is, when an inhaler that works beautifully in one asthmatic fails to help a second person, the reason may well be that they have two different asthmatic illnesses based on genetics.<\/p>\n<p>On thing in common for all the asthma genes is that they all seem to lead to a defect in the epithelial barrier of the airways.\u00a0 This faulty barrier leads to damage from the adaptive immune system, and the resultant airway inflammation.\u00a0 Reason?\u00a0 Because viruses, bacteria and allergens can more easily invade these porous airways.<\/p>\n<p>The second finding was that elevated levels of IgE are not the seminal cause for asthma, but rather occur in response to this airway\u00a0porosity with resultant greater exposure to allergens.<\/p>\n<p>Still, this finding does not negate the fact that therapies directed at elevated IgE are exceedingly helpful\u00a0in treating asthma.<\/p>\n<p>This research will lead to greater efforts at altering gene defects, and also at means to improve the airway epithelail barrier function.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Last month the lead article in the New England Journal of Medicine\u00a0was titled &#8220;A Large-Scale, Consortium-Based Genome-Wide Association Study of Asthma&#8221;, and was from work done by the National Heart and Lung Institute in the U.K. It was a detailed, in-depth study that led to two major findings: First, asthma is genetically heterogenous.\u00a0 This fact accounts for the variability in the illness itself, and also to the variability in response to treatments.\u00a0 That is, when an inhaler that works beautifully&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=72\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[6,34,33],"class_list":["post-72","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-asthma","tag-epithelial-barrier","tag-ige"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/72","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=72"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/72\/revisions"}],"predecessor-version":[{"id":73,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/72\/revisions\/73"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=72"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=72"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=72"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}