{"id":598,"date":"2016-04-12T11:00:35","date_gmt":"2016-04-12T15:00:35","guid":{"rendered":"http:\/\/www.allergy-associates.com\/?p=598"},"modified":"2021-02-16T15:12:25","modified_gmt":"2021-02-16T20:12:25","slug":"drug-hypersensitivity-genetic","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=598","title":{"rendered":"Drug hypersensitivity genetic?"},"content":{"rendered":"

The most common cause for drug allergy is from IgE-mediated (allergic) reactions, such as having hives from penicillin. New research is discovering a second mechanism for drug reaction being called \u201cdrug hypersensitivity,\u201d as it is mediated by T-lymphocytes. The reactions are different from the arch-typical \u201callergy\u201d in that they tend to be somewhat delayed and different types of rashes. Examples are measles-type bumps, the life-threatening skin condition Steven-Johnson Syndrome or liver irritation.<\/p>\n

Of great interest is that there seems to be a genetic predisposition to react to certain individual drugs. Following is a list of certain HLA (genetic) types and the drug that reacts:<\/p>\n

 <\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

Genetic Type<\/b><\/p>\n<\/td>\n

\n

Drug<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

HLA A 31:01<\/p>\n<\/td>\n

\n

Tegretol<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   A 33:03<\/p>\n<\/td>\n

\n

Ticlid<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   A 68:01<\/p>\n<\/td>\n

\n

Lamictal<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   A 02:06<\/p>\n<\/td>\n

\n

Cold Medicines<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   B 56:02<\/p>\n<\/td>\n

\n

Dilantin<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   B 58:01<\/p>\n<\/td>\n

\n

Allopurinol<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   DRB 1 11:01<\/p>\n<\/td>\n

\n

Statins<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   DRB 1 13:02<\/p>\n<\/td>\n

\n

Aspirin<\/p>\n<\/td>\n<\/tr>\n

\n

HLA   C 04:01<\/p>\n<\/td>\n

\n

Viramune<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Because this research is new there are lots of uncertainties. Genetic testing is expensive, and everyone with the implicated gene won\u2019t react to the medicine. It\u2019s too early to recommend across-the-board testing, but an awareness of possibilities, along with finding less expensive ways to do this testing, may soon lead to \u201cgenetic profiling\u201d of all of us.<\/p>\n","protected":false},"excerpt":{"rendered":"

The most common cause for drug allergy is from IgE-mediated (allergic) reactions, such as having hives from penicillin. New research is discovering a second mechanism for drug reaction being called \u201cdrug hypersensitivity,\u201d as it is mediated by T-lymphocytes. The reactions are different from the arch-typical \u201callergy\u201d in that they tend to be somewhat delayed and different types of rashes. Examples are measles-type bumps, the life-threatening skin condition Steven-Johnson Syndrome or liver irritation. Of great interest is that there seems to…<\/p>\n

Read More Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[163],"class_list":["post-598","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-drug-allergy"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/598","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=598"}],"version-history":[{"count":2,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/598\/revisions"}],"predecessor-version":[{"id":1078,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/598\/revisions\/1078"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=598"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=598"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=598"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}