{"id":1366,"date":"2025-02-03T14:25:45","date_gmt":"2025-02-03T19:25:45","guid":{"rendered":"https:\/\/www.allergy-associates.com\/?p=1366"},"modified":"2025-02-03T14:25:45","modified_gmt":"2025-02-03T19:25:45","slug":"dear-dr-k-21","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=1366","title":{"rendered":"Dear Dr. K &#8211;\u00a0"},"content":{"rendered":"\n<p><strong><em>I read that there might be a new asthma controlling shot that is given just every six months.&nbsp; Is that true?&nbsp;<\/em><\/strong>&nbsp;<\/p>\n\n\n\n<p>Yes, it is true.&nbsp; Researchers at Oxford University have just completed two phase 3A randomized placebo control trials that look very promising.&nbsp; The new drug is depemokimab and it is a monoclonal antibody (note the \u201cmab\u201d at the end of its name) that binds to Interleukin 5.&nbsp; In fact, it has an incredibly strong binding affinity for Interleukin 5 which allows for just twice a year dosing.&nbsp; Interleukin 5 is an inflammation causing cytokine that is responsible for the growth, recruitment, activation and survival of eosinophils.&nbsp; Eosinophils are white blood cells that are the cause of most asthma.&nbsp; Make the eosinophils go away and you make the asthma go away.&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>There are other currently available drugs that are also very effective in controlling asthma that target Interleukin 5.&nbsp; But they require more frequent dosing.&nbsp; Also, all of these medications are only indicated in severe asthma that is not adequately controlled with inhaled steroids.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>In the two Oxford trials, depemokimab was very effective in improving asthmatic symptoms and in reducing exacerbations.&nbsp; The side effect profile was similar to that of the placebo control.&nbsp; Still, it won\u2019t be available until it meets FDA approval.&nbsp;&nbsp;&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I read that there might be a new asthma controlling shot that is given just every six months.&nbsp; Is that true?&nbsp;&nbsp; Yes, it is true.&nbsp; Researchers at Oxford University have just completed two phase 3A randomized placebo control trials that look very promising.&nbsp; The new drug is depemokimab and it is a monoclonal antibody (note the \u201cmab\u201d at the end of its name) that binds to Interleukin 5.&nbsp; In fact, it has an incredibly strong binding affinity for Interleukin 5&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=1366\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[6,670,671],"class_list":["post-1366","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-asthma","tag-depemokimab","tag-interleukin-5"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1366","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1366"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1366\/revisions"}],"predecessor-version":[{"id":1367,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1366\/revisions\/1367"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}