{"id":1288,"date":"2023-10-09T14:44:06","date_gmt":"2023-10-09T18:44:06","guid":{"rendered":"https:\/\/www.allergy-associates.com\/?p=1288"},"modified":"2023-10-09T14:44:06","modified_gmt":"2023-10-09T18:44:06","slug":"ple","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=1288","title":{"rendered":"PLE"},"content":{"rendered":"\n<p>PLE stands for protein losing enteropathy and was the subject of a review article in a recent issue of <em>The New England Journal of Medicine<\/em>. PLE is a syndrome not a specific disease and can occur for a wide variety of reasons.&nbsp; The problem is caused by the loss of plasma proteins through the intestines (they \u201cleak\u201d out).&nbsp; In general terms it is caused by illnesses that damage the intestinal lining or that block the intestinal lymphatic drainage.<\/p>\n\n\n\n<p>The resultant loss of proteins causes a drop in oncotic pressure which lead to edema. The loss of immune proteins causes a greater predilection to infections.&nbsp; The most common cause for PLE is inflammatory bowel disease such as regional enteritis or Crohn\u2019s disease.&nbsp; But for our purposes, food allergy, eosinophilic enteritis, and gluten sensitivity are all potential causes.&nbsp; All three of these conditions can cause inflammation in the GI tract and if its is severe enough to cause disruption of the GI tract mucosa and PLE.&nbsp; Clues to this possibility include \u201cGI tumult\u201d, edema in the ankles\/legs, and a low albumin and\/or globulin on blood work.&nbsp; Correcting the cause of inflammation fixes the PLE.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>PLE stands for protein losing enteropathy and was the subject of a review article in a recent issue of The New England Journal of Medicine. PLE is a syndrome not a specific disease and can occur for a wide variety of reasons.&nbsp; The problem is caused by the loss of plasma proteins through the intestines (they \u201cleak\u201d out).&nbsp; In general terms it is caused by illnesses that damage the intestinal lining or that block the intestinal lymphatic drainage. The resultant&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=1288\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[629,630],"class_list":["post-1288","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-ple","tag-protein-losing-enteropathy"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1288","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1288"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1288\/revisions"}],"predecessor-version":[{"id":1289,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1288\/revisions\/1289"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1288"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1288"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1288"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}