{"id":1248,"date":"2023-04-05T15:08:56","date_gmt":"2023-04-05T19:08:56","guid":{"rendered":"https:\/\/www.allergy-associates.com\/?p=1248"},"modified":"2023-04-05T15:08:56","modified_gmt":"2023-04-05T19:08:56","slug":"memory-and-mitochondria","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=1248","title":{"rendered":"<strong>Memory and Mitochondria<\/strong>"},"content":{"rendered":"\n<p>Both the cause and treatment of Alzheimer\u2019s are elusive.&nbsp; Current treatments are modestly effective at best.&nbsp; Recently touted to be the god-send treatment by removing the amyloid plaque the monoclonal therapy (aducanumab and lecanemab) has been a disappointment. &nbsp;&nbsp;<\/p>\n\n\n\n<p>In fact, their failure has led to a shift in focus from the amyloid as the prime culprit to mitochondria.&nbsp; Yes, amyloid deposits are found in the Alzheimer\u2019s brain but so too is found a reduction in mitochondria.&nbsp; Mitochondria are the powerhouse of neuronal cells (actually all human cells).&nbsp; Mitochondria generate the glucose that allows optimal neuron activity and reducing its availability impacts cognition.&nbsp;<\/p>\n\n\n\n<p>But, another factor in the existing mitochondria in Alzheimer\u2019s patients is they have a reduced mitochondria-associated membrane (MAM) electrical function.&nbsp; Excuse the pun, but current theory for our cognition is the electrical field generated by MAM in our brain cells.&nbsp; MAMs are the gatekeepers for ion flux which generates the electrical field.&nbsp; Reduced electrical field leads to neuronal degeneration and loss of cognition.&nbsp;&nbsp; &nbsp;&nbsp;&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Both the cause and treatment of Alzheimer\u2019s are elusive.&nbsp; Current treatments are modestly effective at best.&nbsp; Recently touted to be the god-send treatment by removing the amyloid plaque the monoclonal therapy (aducanumab and lecanemab) has been a disappointment. &nbsp;&nbsp; In fact, their failure has led to a shift in focus from the amyloid as the prime culprit to mitochondria.&nbsp; Yes, amyloid deposits are found in the Alzheimer\u2019s brain but so too is found a reduction in mitochondria.&nbsp; Mitochondria are the&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=1248\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[603,602],"class_list":["post-1248","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-amyloid","tag-mitochondria"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1248"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1248\/revisions"}],"predecessor-version":[{"id":1249,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1248\/revisions\/1249"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}