{"id":1152,"date":"2021-12-08T16:36:06","date_gmt":"2021-12-08T21:36:06","guid":{"rendered":"https:\/\/www.allergy-associates.com\/?p=1152"},"modified":"2021-12-08T16:36:06","modified_gmt":"2021-12-08T21:36:06","slug":"microbiome-and-medicines","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=1152","title":{"rendered":"Microbiome and Medicines"},"content":{"rendered":"\n<p>Previous issues of the <em>Allergic Reaction<\/em> have had several articles about the human microbiome and its impact on health including its effects on the immune system and other systems.&nbsp; Now, add an additional new finding to this list.&nbsp;&nbsp; This research was recently published in <em>Nature<\/em> and it studied interactions of gut bacteria with oral drugs.&nbsp;<\/p>\n\n\n\n<p>Among people who have the same disease a particular medicine can vary greatly in its effectiveness and side effects.&nbsp; Much of this variability has been attributed to genetic differences.&nbsp; This new research indicates that some of the variability is also due to the patients\u2019 gut flora.&nbsp;<\/p>\n\n\n\n<p>Scientists studied the effects of 15 drugs on 25 strains of human gut bacteria and found a remarkable variability in drug-bacteria interactions.&nbsp; For a given medicine some bacteria stored it without modifying it; whereas, other bacteria modified it either to make it more or less bioactive.&nbsp; Either way, the bacteria can lead to the patient receiving a bigger dose or a lower dose of the medicine than was intended. Getting a bigger dose than intended has potential to lead to greater incidence of side effects.&nbsp;<\/p>\n\n\n\n<p>The other side of the research coin showed that some of the drugs altered the growth rate and metabolism of the bacteria.&nbsp; This in turn led to an increase or decrease in the molecules secreted by the gut bacteria including: hormones, neurotransmitters and inflammatory molecules.&nbsp;<\/p>\n\n\n\n<p>At first blush many people are going to feel frustrated by this new level of complexity in how medicines affect us, but scientists have known for a long time this variability in patient response and it was dealt with via \u201ctrial and error\u201d.\u00a0 Hopefully, this new research will lead to a scientific algorhythm for proper dosing based on individual microbiome.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Previous issues of the Allergic Reaction have had several articles about the human microbiome and its impact on health including its effects on the immune system and other systems.&nbsp; Now, add an additional new finding to this list.&nbsp;&nbsp; This research was recently published in Nature and it studied interactions of gut bacteria with oral drugs.&nbsp; Among people who have the same disease a particular medicine can vary greatly in its effectiveness and side effects.&nbsp; Much of this variability has been&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=1152\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[556],"class_list":["post-1152","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-microbiome-and-medicines"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1152"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1152\/revisions"}],"predecessor-version":[{"id":1153,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1152\/revisions\/1153"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}