{"id":1136,"date":"2021-08-05T09:26:25","date_gmt":"2021-08-05T13:26:25","guid":{"rendered":"https:\/\/www.allergy-associates.com\/?p=1136"},"modified":"2021-08-05T09:26:25","modified_gmt":"2021-08-05T13:26:25","slug":"dear-dr-k-i-received-bcg-treatments-for-my-bladder-cancer-now-i-hear-it-is-being-used-for-diabetes-is-that-true","status":"publish","type":"post","link":"https:\/\/www.allergy-associates.com\/?p=1136","title":{"rendered":"Dear Dr. K; I received BCG treatments for my bladder cancer.  Now I hear it is being used for diabetes.  Is that true?"},"content":{"rendered":"\n<p>The one second answer is \u201cyes\u201d, but there is an over 100-year-old story behind that.&nbsp; BCG, properly called Bacillus Calmette-Guerin is a live attenuated (weakened) form of tuberculosis.&nbsp; The vaccine has been around for 100 years and is routinely given to children in nearly all non-Western countries to prevent TB.&nbsp; Not long after the vaccine was developed in the 1920\u2019s scientists noted a significant decrease in childhood death rates not only from TB but from many unrelated infections.&nbsp; More recent studies in elderly patients showed a marked reduction in all forms of respiratory infections in mature adults receiving BCG as compared to a placebo shot.&nbsp;<\/p>\n\n\n\n<p>These observations have led to a broader scope of research on BCG around the globe.&nbsp; Here in the US, Harvard Medical School is a front runner in this research.&nbsp; As weird as it may seem it turns out that BCG can not only boost good immunity but paradoxically can also calm an overactive immune system that is causing auto-immune disease.&nbsp; The Harvard team found that BCG triggers the immune system to produce TNF-alpha which does two important jobs.&nbsp; TNF-alpha fights all types of bacterial and viral infections but it also helps the body make T-regulatory cells (T-regs) which act as<\/p>\n\n\n\n<p>\u201creferees\u201d to prevent collateral damage during immune responses.&nbsp;<\/p>\n\n\n\n<p>Unlike type II diabetes, which is due to obesity causing insulin resistance with very high insulin levels, Type I diabetes is due to a lack of insulin production by the pancreas because of an auto-immune destruction of the cells that produce insulin.&nbsp; BCG given as type I diabetes is developing can save some of the pancreas cells that produce insulin before they are all destroyed.&nbsp;<\/p>\n\n\n\n<p>Alzheimer\u2019s disease is currently viewed as an auto-immune disease in the brain where chronic inflammation leads to the amyloid plaque (scar tissue) that disrupts nerve connections.&nbsp; A research group in Israel recently reported on a large cohort of people with bladder cancer.&nbsp; Those who received BCG as a treatment for their bladder cancer had a 2.4 percent occurrence of Alzheimer\u2019s years later versus an 8.9 percent occurrence in a group who did not receive BCG.&nbsp;<\/p>\n\n\n\n<p>This observation has sparked ongoing trials of using BCG in treating early Alzheimer\u2019s and also in MS (multiple sclerosis) another auto-immune brain disease.&nbsp; Other ongoing areas of research using BCG include preventing Covid 19 infection, treating eczema and asthma.&nbsp;<\/p>\n\n\n\n<p>The United States and some other Western nations have never adopted the use of BCG as a prevention for TB, opting instead to treat individual cases as they occur.&nbsp; Pending the outcome of these recent research trials, that policy might change.&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The one second answer is \u201cyes\u201d, but there is an over 100-year-old story behind that.&nbsp; BCG, properly called Bacillus Calmette-Guerin is a live attenuated (weakened) form of tuberculosis.&nbsp; The vaccine has been around for 100 years and is routinely given to children in nearly all non-Western countries to prevent TB.&nbsp; Not long after the vaccine was developed in the 1920\u2019s scientists noted a significant decrease in childhood death rates not only from TB but from many unrelated infections.&nbsp; More recent&#8230;<\/p>\n<p class=\"read-more\"><a class=\"btn btn-default\" href=\"https:\/\/www.allergy-associates.com\/?p=1136\"> Read More<span class=\"screen-reader-text\">  Read More<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[552,553],"class_list":["post-1136","post","type-post","status-publish","format-standard","hentry","category-uncategorized","tag-bcg","tag-bladder-cancer"],"_links":{"self":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1136"}],"version-history":[{"count":1,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1136\/revisions"}],"predecessor-version":[{"id":1137,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=\/wp\/v2\/posts\/1136\/revisions\/1137"}],"wp:attachment":[{"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.allergy-associates.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}